BNR/Asp-box repeat

BNR/Asp-box repeat
Structure of a bacterial sialidase.[1]
Identifiers
Symbol BNR
Pfam PF02012
Pfam clan CL0434
InterPro IPR002860
SCOP 1euu

BNR/Asp-box repeat' is a repetitive sequence of amino acids contained in some proteins.

Members of this family contain multiple BNR (bacterial neuraminidase repeat) repeats or Asp-boxes. The repeats are short, however the repeats are never found closer than 40 residues together suggesting that the repeat is structurally longer. These repeats are found in a variety of non-homologous proteins, including bacterial ribonucleases, sulphite oxidases, reelin, netrins, sialidases, neuraminidases, some lipoprotein receptors, and a variety of glycosyl hydrolases.[2]

Members of this family contain multiple BNR (bacterial neuraminidase repeat) repeats or Asp-boxes.

The repeats are short, however the repeats are never found closer than 40 residues together suggesting that the repeat is structurally longer. These repeats are found in many glycosyl hydrolases as well as other extracellular proteins of unknown function.

Examples

Human genes encoding proteins containing this domain include:

NEU1, NEU2, NEU3, RELN, SORCS1, SORCS2, SORCS3, SORL1, SORT1

References

  1. ^ Gaskell A, Crennell S, Taylor G (November 1995). "The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll". Structure 3 (11): 1197–205. PMID 8591030. 
  2. ^ Ponting CP, Russell RB, Copley RR (2001). "Sialidase-like Asp-boxes: sequence-similar structures within different protein folds". Protein Sci. 10 (2): 285–292. doi:10.1110/ps.31901. PMC 2373934. PMID 11266614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2373934. 

This article incorporates text from the public domain Pfam and InterPro IPR002860